个人经历：

2019年6月毕业于天津大学生物学专业获理学博士学位。2019年9月加入分子+研究院从事博士后研究工作。2021年5月晋升为副研究员。主要研究方向为药学及功能分子设计、药理药效学研究及评价。作为主要参与人推动1类创新药物临床默示许可申请2项。

发表论文：

1.     Shengnan Liu, Ziru Sun, Min Liang, Weijie Song, Ru Zhang, Yunli Shi, Yujun Cui*, Qingzhi Gao*. An Unrevealed Molecular Function of Corannulene Buckybowl Glycoconjugates in Selective Tumor Annihilation by Targeting the Cancer-Specific Warburg Effect. Advanced Science, 2022, 9, 2105315.

2.     Shengnan Liu*, Weijie Song, Yujun Cui, Ziru Sun, Zhenhua Huang, Qingzhi Gao*. A GLUT1 inhibitor-based probe significantly ameliorates the sensitivity of tumor detection and diagnostic imaging. Chem Commun, 2021, 57: 5530-5533.

3.     ShunjieZhang^#, XinyuWang^#, RuZhang^#, YujunCui, HemingZhanga, WeijieSong, XiaohanHou, ShiboFu, Qingzhi Gao*, Shengnan Liu*.A GLUT1 inhibitor-based fluorogenic probe for Warburg effecttargeted drug screening and diagnostic imaging of hyperglycolytic cancers. Analytica Chimica Acta, 2021, 1167: 338593.

4.     Yang Li^#, Shengnan Liu^#, Min Liang, Yujun Cui, Hongxia Zhao*, Qingzhi Gao*. Glycocalixarene with Luminescence for Warburg Effect-mediated Tumor Imaging and Targeted Drug Delivery. Chem Commun, 2021, 57: 9728-9731.

5.     Yaru Li^#, Ziru Sun^#, Yujun Cui, Heming Zhang, Shunjie Zhang, Xinyu Wang, Shengnan Liu*, Qingzhi Gao*. Oxaliplatin derived monofunctional triazole-containing platinum(II) complex counteracts oxaliplatin-induced drug resistance in colorectal cancer. Bioorganic Chemistry, 2021, 107: 104636.

6.     Zizhen Li#, Heng Jiang#, Shengnan Liu, Yuxin Li, Zhiguang Yuchi*, Qingzhi Gao*. Ryanodine receptor-targeting small molecule fluorescent probes enables non-isotopic labeling and efficient drug screening for green insecticides. Analytica Chimica Acta, 2020, 1108: 108-117.

7.     Shengnan Liu, Weijie Song, Xiangqian Gao, Yanxin Su, Emily Gao, Qingzhi Gao*. Discovery of Nonpeptide, Reversible HER1/HER2 Dual-Targeting Small-Molecule Inhibitors as Near-Infrared Fluorescent Probes for Efficient Tumor Detection, Diagnostic Imaging, and Drug Screening. Analytical Chemistry, 2019, 91: 1507-1515.

8.     Xiangqian Gao, Shengnan Liu, Yunli Shi, Zhenhua Huang, Yi Mi, Qian Mi, Jinna Yang, Qingzhi Gao*. Mechanistic and biological characteristics of different sugar conjugated 2-methyl malonatoplatinum(II) complexes as new tumor targeting agents. European Journal of Medicinal Chemistry, 2017, 125: 372-384.

9.     DepingWang^#, ChengChen^#, Shengnan Liu^#, Han Zhou^#, KailinYang, Qi Zhao, Xiaoyun Ji, Chen Chen, WeiXie, ZefangWang, Li-Zhi Mi*, HaitaoYang*. A mutation identified in neonatal microcephaly destabilizes Zika virus NS1 assembly in vitro. Scientific Reports, 2017, 7: 42580.

科研项目：

1.     国家重点研发计划：天然绿色生物农药的合成生物学与组合合成技术。2017YFD0201400，参与。

2.     国家重点研发计划：重要植物天然产物的途径创建。2020YFA0907900，参与。

3.     横向合作：基于深度学习和云端超算的新药高通量筛选系统建设（前期研究第一期），主持。

4.     自主创新基金：合成生物学前沿科学中心建设。2021XY-0005，主持子课题。

专利情况：

1.     高清志, 刘胜男, 高香倩. 一种用于检测或治疗肿瘤的近红外荧光探针. 201810781662.5. 

2.     高清志, 刘胜男, 石蕴丽. 一种用于检测肿瘤的荧光探针及用途.2018103599111.

3.     一种用于检测肿瘤特异性蛋白的荧光配体及用途.201810359911.1.

4.     高清志, 李子真, 刘胜男, 姜恒. 一种用于筛选作用于鱼尼丁受体药物的荧光配体.201910283307.X.

5.     高清志, 侯晓涵, 刘胜男, 赵红霞. 靶向肿瘤沃伯格效应的肿瘤诊断和治疗荧光探针. 202010545929.8.

6.     高清志, 刘胜男, 王欣瑜. 一种细胞糖转运通道抑制剂. 2021104118708.

7.     赵红霞,刘胜男, 李扬, 高清志. 用于检测肿瘤的糖基杯芳烃荧光探针.2021105059035.